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May 1, Vol. 32, No. 9

  • Feature Articles

    • Advancing Beyond the Genome with Affinity Proteo...
    • Kate Marusina, Ph.D.
    • Until recently, the field of disease proteomics was focused on separation techniques coupled with mass-spectrometric identification of proteins However, technological limitations due to patient-to-patient variability and loss of signal from low-abundance proteins have lead researchers to a different technique: affinity ... more »
    • Metabolomics Continues Auspicious Climb
    • Jeffery Herman, Ph.D.
    • Aberrant biochemical and metabolite signaling plays an important role in the development and progression of diseased tissue This concept has been studied by the science community for decades However, with relatively recent advances in analytical technology and bioinformatics as well ... more »
    • Drivers and Hurdles for qPCR
    • Mikael Kubista, Ph.D.
    • According to a recent report on the gene-amplification technologies market from Global Industry Analysts, there are close to 70,000 bioresearchers using real-time quantitative PCR (qPCR) in North America alone They spend $740 million annually on instruments and reagents Annual growth, ... more »
    • Biomarker Discovery Methods Evolving
    • Greg Crowther, Ph.D.
    • Biomarker research has made substantial progress recently beyond the proverbial low-hanging fruit Emerging technologies and techniques are helping make biomarker detection and application faster, cheaper, and more diverse This was the focus of talks at GTC’s recent “Biomarker Summit” conference... more »
    • Mathematics Transforming Bioresearch
    • Mitzi Perdue
    • Human and animal health, agriculture, energy production, environmental protection, and a host of other activities of interest to humans have something startling in common: the key to improvements in all of them is likely to require a significant computational component... more »
  • Columns

    • People in the News
    • Mike Evans, PhD , is now nonexecutive chairman for TAP Biosystems Dr Evans had been a nonexecutive director of TAP since 2005 and has worked in the life science industry for over 20 years with companies including GE Healthcare ... more »
    • Step Up for Biotechnology
    • Ron Cohen, M.D.
    • The US is now facing unprecedented competition from around the globe to be the leader in biomedical research In 2008, China pledged to invest $12 billion in drug development, and in 2011, the Chinese government named biotechnology as one of ... more »
    • Next-Gen Sequencing Services
    • Christianne Bird
    • Much of the media and investor attention paid to next-generation sequencing surrounds the instrumentation market However, the sequencing services market is growing as well, at a projected compound annual growth rate (CAGR) of 28% from 2011 to 2016, an astounding ... more »
    • Gene Therapy Briefs
    • Amsterdam Molecular Therapeutics published data in the Journal of Clinical Endocrinology & Metabolism demonstrating that one-time administration of the gene therapy Glybera® (alipogene tiparvovec) in five patients markedly improved chylomicron metabolism 14 weeks after consuming a low-fat meal. That improved ... more »