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September 1, Vol. 31, No. 15

  • Feature Articles

    • Global Incentives Seek to Buoy Innovation
    • Vicki Glaser
    • Global representation at the 2011 BIO meeting was extensive Countries, regional clusters, individual states, research consortia, and universities each showcased the advantages of its infrastructure, resources, location, economic incentives, workforce, and cultural characteristics that make it attractive to entrepreneurs and ... more »
    • Transfection Practices Change with Times
    • John Russell
    • Transfection technology for inserting nucleic acids into cells is getting a boost from novel electroporation techniques, new reagents, and easier-to-use transfection platforms One leading-edge example is work being done by Virginia Tech associate professor Chang Lu, PhD Dr Lu's approach ... more »
    • Omics-Related Research On Rise in China
    • Jim J. Zhang, Ph.D.
    • Molecular biomarkers and diagnostics are playing increasingly important roles in the modern pharmaceutical and healthcare industries To more efficiently discover drugs, companies now increasingly apply these technologies in order to find the right drug for the right patient These efforts ... more »
    • Tackling DNA Vaccine Production
    • K. John Morrow Jr.
    • Delivery, delivery, delivery is the major focus of DNA vaccine research, according to David Weiner, PhD, University of Pennsylvania professor and also chair of the recent conference on “DNA Vaccines: Building on Clinical Progress and Exploring New Targets”... more »
    • Evaluating Bioprocess Monitoring Options
    • Angelo DePalma, Ph.D.
    • Spectrometric techniques like near-infrared (NIR) and Raman are among the most appealing alternatives to traditional sensors for bioprocess monitoring These techniques are robust, scalable, and capture tremendous quantities of process data in real time Their only drawbacks are that they ... more »
    • Engineering Regenerative Medicine's Future
    • Stuart Kay
    • Stakeholders in the regenerative medicine sector recognize that the commercialization of novel therapeutic interventions faces a number of bottlenecks before these treatments can be adopted by existing healthcare providers Since companies focused on regenerative medicine first attracted investment, many firms ... more »
    • GEN's 30th Anniversary: Tax Advantaged Limited P...
    • As the biotech industry moves forward into its fourth decade, much has changed since the early 1980s There is an ongoing stream of new biopharmaceutical products and diagnostics, novel instrumentation and cutting-edge tools, innovative start-up biofirms based all over the ... more »
  • Columns

    • Revamping Research Funding
    • Jonathan Yewdell
      Howard Young
    • During the decades of increasing NIH budgets, the process and mechanism for funding biomedical research in the US was largely successful However, with the onset of level or decreased funding following the golden era of budget doubling, the current system ... more »
    • Protecting Diagnostic Inventions in the U.S.
    • David A. Gass
    • Effective patent protection for medical diagnostics is best achieved with a patent-drafting strategy that shows foresight for the complexities of patent enforcement Under 35 USC §271(a), whoever without authorization makes, uses, sells, or imports a patented invention may be liable ... more »
    • Chinese Genomics Firm Expands Operations
    • Carol Potera
    • When a deadly foodborne strain of Escherichia coli recently killed dozens of people in Europe, researchers at BGI (formerly Beijing Genomics Institute) teamed up with collaborators at the University Medical Centre Hamburg-Eppendorf to sequence the microbe's genome They determined that ... more »
    • T-Cell Therapy Eradicates CLL in Trial
    • Patients treated in an early clinical trial evaluating engineered autologous T-cell therapy for advanced chronic lymphocytic leukemia (CLL) have had their tumors “blown away,” according to the trial investigators at the University of Pennsylvania School of Medicine The trial involved ... more »