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July 1, Vol. 31, No. 13

  • Feature Articles

    • Harnessing Nuclear Receptors
    • Kathy Liszewski
    • Nuclear receptors drive many critical processes ranging from metabolism to reproduction by serving as ligand-activated transcription factors They also represent a lucrative area for drug discovery as evidenced by current therapies utilizing glucocorticoids for asthma, estrogens for hormone-replacement therapy, and ... more »
    • Alleviating Downstream Process Bottlenecks
    • Eric S. Langer
    • Over two-thirds of biopharmaceutical manufacturers now report that their facility is experiencing capacity bottlenecks due to downstream processing A number of factors continue to converge to create these constraints As shown in our 8th Annual Report and Survey of Biopharmaceutical ... more »
    • Central Eastern Europe Targets Biotech
    • Sue Pearson, Ph.D.
    • This year’s “BioForum 2011” conference in Lodz, Poland, exposed the good and the bad about Central Eastern Europe’s (CEE) biotech industry The good news is that CEE is beginning to establish a biotech presence: there are over 200 companies (many ... more »
    • GEN's 30th Anniversary: Factor VIII Gene Cloned ...
    • One of the refrains the fledgling biotech industry kept hearing from the investment community in the early 1980s was, “When are we going to see products?” Such was the hope, and hype, surrounding the bioindustry then as many observers expected ... more »
    • Multiplexing Brings HTS to Higher Level
    • K. John Morrow Jr.
    • Multiplex assays are based on single-analyte tests or low-to-midplex procedures that typically predate the rise of their multiplex versions They may include vast numbers of analytes in a single assay and require specialized technologies or miniaturization to achieve a higher ... more »
    • DNA Cloning Expands into New Horizons
    • Richard A. Stein
    • One of the most indispensable techniques in all areas of the life sciences is the use of expression vectors Cloning a gene between two restriction sites, and the expression of a protein, are almost always taken for granted—but a frequently ... more »
    • Strategies for Optimizing Peptide Synthesis
    • Vicki Glaser
    • The environmental impact of large-scale peptide production can be staggering In his presentation at the “Avakado Media Peptide” conference held in April, Mimoun Ayoub, PhD, vp global business and strategic development at Peptisyntha (a Solvay company), noted that the production ... more »
    • Regenerative Medicine Field Takes Shape
    • Gail Dutton
    • The pioneering status of regenerative medicine is forcing developers and regulators to write the rules as they go, resulting in a highly collaborative regulatory environment that builds the framework for all subsequent regenerative therapies Speakers at the recent “World Stem ... more »
    • aCGH Opens Up Novel Avenues of Study
    • Angelo DePalma, Ph.D.
    • Array-based comparative genomic hybridization (aCGH) has become a standard method for detecting copy-number variations (CNVs) and other genetic defects associated with genetic diseases Once primarily the domain of postnatal testing for developmental disorders, the technique is branching into prenatal (and ... more »