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February 15, Vol. 31, No. 4

  • Feature Articles

    • GEN 30th Anniversary: HIV/AIDS
    •  It was 30 years ago in 1981 that the first known case of acquired immune deficiency syndrome (AIDS) was definitively diagnosed According to last year’s “UNAIDS Report on the Global AIDS Epidemic”, 314-353 million people around the world were living ... more »
    • Gene Delivery on a Rebound
    • Josh P. Roberts
    • Cries of “reports of gene therapy’s death have been greatly exaggerated” tend to be in a never-ending cycle with “gene therapy is dead” Judging by the recent Congress of the European Society for Gene and Cellular Therapy, it looks like ... more »
    • New Frontiers Open Up in Molecular Diagnostics
    • Kate Marusina, Ph.D.
    • Few clinical niches are currently spared from the reach of novel genomic technologies Molecular analysis technologies enable the parsing of biological pathways with previously unattainable granularity Stratifying patient populations based on their genetic markers is becoming a clinical reality In ... more »
    • Surface Plasmon Resonance Branches Out
    • Ellyn Kerr
    • With its unique capacity for label-free, real-time generation of detailed information on binding interactions, surface plasmon resonance (SPR) has established itself as a mainstay in drug discovery research Long-time market incumbents and newer SPR instrumentation suppliers alike are addressing the ... more »
    • Value of PCR Amplified as It Moves to Clinic
    • Vicki Glaser
    • The polymerase chain reaction (PCR), long a tried-and-true tool in the research setting, is increasingly the basis for clinical tests aimed at improving disease diagnostic and prognostic capabilities, monitoring disease progression, and, increasingly, predicting drug response and adverse reaction or ... more »
    • Single-Use Implementation a Group Effort
    • Gail Dutton
    • Single-use biomanufacturing systems promise to reduce the risk of cross-contamination, provide low-cost scaleup, and allow multiple products to be manufactured at a single site with minimal validation issues While all of this is true, they are not necessarily plug-n-play Instead, ... more »
    • Biomanufacturers Weigh In on Disposables
    • Eric S. Langer
    • Biomanufacturers and CMOs are becoming increasingly vocal about the lack of new product innovation from their suppliers But nowhere is that more painfully apparent than for single-use devices In this year’s “8th Annual Report and Survey of Biomanufacturing Capacity and ... more »
    • IDBS Set to Optimize Bioprocesses at Lonza
    • John Sterling
    • Lonza selected IDBS to provide an electronic data-management and execution solution for mammalian cell culture process development Lonza officials said they will use IDBS’ Bioprocess Execution System (BPES) to optimize the management of process development data for Lonza customers... more »
    • Crick Progeny Follow Their Own Passions
    • Carol Potera
    • Do famous scientists spawn like-minded offspring? For Francis Crick, the co-discoverer of the structure of DNA and Nobel laureate, the answer is partially true His son Michael Crick studied neuroscience at Harvard Medical School in the 1960s but sidetracked into ... more »