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January 1, Vol. 31, No. 1

  • Feature Articles

    • Adapting Protein Expression for HT
    • Josh P. Roberts
    • The three most important things when expressing protein for high-throughput applications are: optimize, optimize, optimize Put the best genes you can into your expression system, use the most fitting expression systems, and make sure the growth conditions are suited to ... more »
    • Novel Methods Expedite Nucleic Acid Sample Prep
    • K. John Morrow Jr.
    • Recent developments in genomic identification using microarray technologies are infiltrating the fields of forensics, diagnostics, and sample identification They include a combination of new hardware designs and innovative approaches to sample processing In addition, microfluidics and miniaturization are emerging as ... more »
    • Enabling Tools Extend the Range of HCA
    • Vicki Glaser
    • At the Image Informatics and Computational Biology Unit in the Laboratory of Genetics at the NIH, Ilya Goldberg, PhD, head of the unit, and colleagues are developing computational strategies based on pattern recognition to derive and interpret quantitative measurements from ... more »
    • Single-Use Systems Become the Norm
    • Angelo DePalma, Ph.D.
    • Over the last few years, disposable biomanufacturing has shed its reputation for isolated, low-tech storage and hold applications to an over-arching strategy appropriate for every stage in a product’s manufacturing life cycle Aiding this trend have been awareness of the ... more »
    • Power in Numbers for Cancer Biomarkers
    • Kate Marusina, Ph.D.
    • It is no longer believed that dysregulation of limited amounts of oncogenes or tumor-suppressor genes causes cancer Cancer cells show aberrant regulation of many other genes directly or indirectly involved in carcinogenesis and tumor progression Therefore, observation of a single ... more »
    • Solving the Antithrombotic Conundrum
    • David J. Mazzo, Ph.D.
    • The multibillion-dollar worldwide market for injectable antithrombotic drugs (including anticoagulants and antiplatelet agents) will continue to grow as minimally invasive surgical interventions to open blocked coronary vessels become increasingly commonplace... more »