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July 1, Vol. 30, No. 13

  • Feature Articles

    • Spotlight on Opportunities & Innovations
    • Vicki Glaser
    • International opportunities for outsourcing of drug discovery and development research, preclinical studies, clinical trials, and product manufacturing, as well as the allure of large, untapped global markets for new and existing drugs, were the focus of several sessions at BIO’s ... more »
    • CRO Relationships Get More Serious
    • Elizabeth Lipp
    • The consolidation of pharma is the elephant in the room; it’s not news that recent acquisitions have had global ramifications in the industry The economic downturn and the need to reinvigorate the drug discovery pipeline have shaken out to a ... more »
    • Real-Time PCR Advances Show Promise
    • Nina Flanagan
    • Since the origin of PCR in 1983, there have been many enhancements and adaptations Current trends, recently cited in a report by HTStec ( qPCR Assay Trends, 2008), indicate a focus on faster reagents, shorter run times, and new applications ... more »
    • Biomagnetic Separations' Abilities Increase
    • Gail Dutton
    • After years of minor tweaks to biomagnetic separation technology, manufacturers are introducing major product additions that support molecular diagnostics, cell therapy, stem cell separations, and other new markets, as well as new separation devices that include microfluidics, modularity, and enhanced ... more »
    • Filtration Evolves to Meet Users' Needs
    • Angelo DePalma, Ph.D.
    • High protein titers have been blamed, at least in part, for the mismatches of equipment, time, and facilities that result in downstream bottlenecks in chromatography and filtration operations Less appreciated are upstream challenges due to an enabler of high-titer processing, ... more »
    • Biological Scaffolds for ReGen Medicine
    • Patricia Fitzpatrick Dimond
    • Biological scaffolding, either alone or in combination with cells for tissue regeneration, has the potential to revolutionize the repair of injured tissues and to replace tissues lost through disease and injury Requirements for scaffolding include biocompatibility, hemocompatability, and the use ... more »
  • Columns

    • Biomarker-Oriented Business Models in Flux
    • Rod Raynovich
    • Genomics transformed biology, and now we are seeing its initial impact on drug development and personalized diagnostic services, particularly in cancer While progress is indeed being made in biomarker discovery, there are various issues to consider just in terms of ... more »
    • Using Continuous Flow to Mimic Capillaries
    • Ilene Schneider
    • As postgraduate students in the department of physics and clinical medicine at Trinity College, Dublin, Vivienne Williams and Dmitry Kashanin were working on a project to investigate microfluidics and develop biochips for cell-based experiments They developed a technology to mimic ... more »
    • Point-of-Care Testing Impacts Outcomes
    • Isaac Middendorf
    • Point-of-care testing (POCT) includes professional-grade in vitro diagnostic tests completed in close proximity to patients By performing diagnostic tests closer to patients and obtaining results directly at the point-of-care, primary care providers can immediately diagnose and treat patients for improved ... more »