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June 1, Vol. 30, No. 11

  • Feature Articles

    • Multiplexing Advances Redefine HTS
    • K. John Morrow Jr.
    • Multiplexing is a critical component of rapid screening technologies At the annual meeting of the Society for Biomolecular Sciences held recently in Phoenix, a number of industry and academic scientists explained their pursuit of novel technologies that allow assays to ... more »
    • Microwave Chemistry Speeds Up Discovery
    • It turns out that almost the same process you use to warm your Stouffers Macaroni and Cheese dinner might also help your research team find novel therapeutics In addition, it looks like microwaves can accelerate peptide synthesis as well GEN’s ... more »
    • Surmounting siRNA Delivery Obstacles
    • Kathy Liszewski
    • Despite considerable challenges, RNA interference (RNAi) as a therapeutic strategy continues to draw excitement and scrutiny Two recent meetings—Select Biosciences’ “RNAi and miRNA World Congress” and “RNAi 2010”—provided updates on the field A number of presentations focused on  advances in ... more »
    • Maximizing HPLC Power and Throughput
    • Vicki Glaser
    • The plasma glycome represents a potential source of disease biomarkers Changes in glycosylation of glycoproteins are often associated with inflammatory and other acute-phase disease responses and may provide a tool for early disease detection In breast cancer, detectable glycan changes ... more »
    • Due Diligence Essential in Selecting CMO
    • At their foundation, business relationships with contract manufacturing organizations (CMOs) are about relationships with people In a niche in which nearly all of the providers have state-of-the-art equipment, modern facilities, experienced employees, and leaders familiar with the industry, savvy biotechs ... more »
  • Columns

    • Precautionary Regulation Is What's Rotten in Den...
    • Henry I. Miller, M.D.
    • Controversies continue over the appropriate regulation of a variety of technologies, activities, and consumer products, including nuclear power, chlorinated water, pesticides, hormones in beef, and emissions of greenhouse gases An underlying fundamental, almost philosophical question is, how should regulators, acting ... more »
    • Testing Services Fueling Growth in Cancer Dx
    • Bruce Carlson
    • Cancer is among the world’s deadliest and most costly diseases; it is the number two killer after cardiovascular disease and for this reason improvements to existing treatments are aggressively sought As a result, cancer applications provide test makers greater opportunities ... more »
    • Changes Looming in Hepatitis C Arena
    • Adam Cutler
    • The treatment of chronic hepatitis C virus (HCV) infection is on the verge of a major transformation New drugs in the late stages of development have the potential to increase cure rates, shorten the length of therapy, and entice significant ... more »
    • SmartPlex Platform
    • Officials at Thermo Fisher Scientific say the company’s new SmartPlex platform shifts microarrays to a 96-well configuration, thus evolving toward an ELISA-like format that increases the speed and volume of multiplex applications Because it conforms to SBS microplate standards, SmartPlex ... more »
    • Accelrys Launches Pipeline Pilot 8.0
    • Accelrys released Pipeline Pilot™ 80, its scientific informatics platform Company officials say that the product has been further developed to support a greater number of scientists and researchers working individually or as collaborative teams across the wider scientific R&D enterprise... more »