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May 1, Vol. 30, No. 9

  • Feature Articles

    • New Tools Facilitate Protein Expression
    • Kathy Liszewski
    • Many challenges confront researchers attempting to express recombinant proteins Post-translational modifications, quantity produced, and recapitulating function are chief among them These and other issues will be discussed at CHI’s “Difficult to Express Proteins” conference to be held later this month ... more »
    • Nucleic Acid Sample Prep
    • Vicki Glaser
    • A common theme of many of the presentations at the Knowledge Foundation’s “Sample Prep” conference, to be held this month in Baltimore, will be how to purify nucleic acids, including DNA, RNA, and miRNA, from different types of samples using ... more »
    • Driving Successful Assay Development
    • Ken Niebling, Ph.D.
    • Since biological therapeutics are derived from living organisms, their manufacture and validation presents difficulties not encountered during traditional small molecule drug development Despite the complexities inherent in developing biologics, there are a growing number of licensed biological products on the ... more »
    • Leveling Downstream Process Bottlenecks
    • Angelo DePalma, Ph.D.
    • Due to the complexity of therapeutic protein purification, downstream bioprocess bottlenecks can arise from almost anywhere, from capacity or facility mismatches to scheduling Although their sources and bottom-line impact may be debated, bottlenecks are real and their alleviation has become ... more »
    • Firms Get a Handle on Injectable Delivery
    • Nina Flanagan
    • Continued progress in drug discovery and development is increasing the potential number of injectable drugs As a result, pharmaceutical companies are collaborating with drug delivery firms to address patients’ concerns and needs, and to maximize revenues Management Forum’s recent “Injectable ... more »
    • Lightning Strikes Cryptogram Winners Twice
    • For the first time since the series of contests began in November 2008, the same individuals have won prizes for successfully figuring out the answers to two different “GEN Cryptogram Challenges”... more »
  • Columns

    • Genetic Testing Registry Benefits
    • Sharon F. Terry
    • After several years of calls for a mandatory genetic tests registry from Genetic Alliance, the Genetics and Public Policy Center, the Coalition for 21st Century Medicine, and others, the National Institutes of Health (NIH) has finally taken the first step ... more »
    • Emerging Vaccines Set to Shake Up Market
    • Bruce Carlson
    • There are myriad challenges that healthcare providers face today including: spiraling costs, an aging population, the rapid globalization of diseases, and diseases for which there is no treatment A product that could solve all of these problems would be wildly ... more »
    • Reform Will Likely Beget Biologic Bonanza
    • Viren Mehta
    • The 12-year data exclusivity period for biologics, effectively ensuring that no biologic drug will have less than 12 years of market exclusivity after launch, along with several other incentives in healthcare reform legislation, promise to continue the R&D shift in ... more »
    • Cardioxyl Attempts to Beat Heart Disease
    • Carol Potera
    • Nitric oxide’s beneficial biological effects are well known and form the foundation of drugs used to treat heart disease and erectile dysfunction A chemical relative, nitroxyl, is emerging as a promising new option for cardiovascular disorders, according to researchers at ... more »