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May 1, Vol. 29, No. 9

  • Feature Articles

    • Emerging Biotechnology Clusters
    • Gail Dutton
    • Boston, San Francisco, San Diego, and Cambridge are on everyone’s list of the top biotech clusters Medicon Valley, straddling the border of Sweden and Denmark, Switzerland’s BioValley, Seattle, and Paris may be on that list, too, and no wonder These ... more »
    • ADMET Increasingly Integral to Discovery
    • Elizabeth Lipp
    • Preclinical in vitro testing for ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties has come a long way in the decade since it became an important consideration in the discovery process But it still has a long way to go... more »
    • Novel Ways of Looking at Old Problems
    • K. John Morrow Jr.
    • The exponential increases in yields of recombinant proteins by various expression systems continue to place demands on the downstream end of the process Proteins generated at high densities can take on undesirable properties as the molecules crowd together... more »
    • Oligo Market Benefits from RNAi Focus
    • Vicki Glaser
    • Despite the global economic downturn, CMOs and producers of oligonucleotides for research, therapeutic, and diagnostic applications remain optimistic that the healthy growth rate enjoyed over the past few years will continue While some drug companies may delay development projects until ... more »
    • HPLC Thrives on Speed and Efficiency
    • Angelo DePalma, Ph.D.
    • The success of UHPLC (ultrahigh-performance liquid chromatography) in its various forms has been a pleasant surprise All major vendors have released, in one form or another, high-end, high-pressure systems employing columns with stationary-phase particle sizes below 25 microns Not everyone ... more »
  • Columns

    • PharmAthene Secures Biodefense Position
    • Carol Potera
    • The threat of bioterrorism will likely always loom over us Bolstering the nation’s biodefense arsenal provides a new arena and opportunities for biotech companies PharmAthene was among the first companies to enter the biodefense field in 2001 Its mission all ... more »
    • VC Lock-Down Mode Paralyzes Bioindustry
    • Rod Raynovich
    • This time the biotech industry consolidation is for real The gloomsayers who predicted an industry downsizing in the past were wrong, but this time they are right The trillion dollar black hole of derivative speculation has curbed the appetite for ... more »
    • Securing a Slice of NIH Stimulus Funding
    • Christianne Bird
    • The 2009 US American Recovery and Reinvestment Act (ARRA) has many life science tool companies abuzz with anticipation of new research funds helping their firms reverse the damages of the economic recession The 2009 economic recovery bill contains $104 billion ... more »
    • Identifying Cardiotoxic Compounds
    • Blake Anson
      Junyi Ma
      Jia-Qiang He
    • Novel pharmaceutical discovery and development is an expensive, difficult, and inefficient process, primarily due to the lack of models that accurately present the appropriate condition or that reflect the appropriate response Ascertaining potential efficacy and off-target toxicity is a large ... more »
    • Automated Capillary Isoelectric Focusing
    • “The PA 800 plus Pharmaceutical Analysis System automates SDS-gel, isoelectric focusing, and glycan analysis of monoclonal antibodies and other therapeutic proteins,” according to Mark Lies and Hans Dewald, capillary electrophoresis product managers at Beckman Coulter The platform integrates quantitative, qualitative, ... more »
    • Sugars Are Sweet
    • Glycosylation is one of the most hotly debated phenomena in biotechnology, particularly for development of biosimilars Regulators are still unsure how glycosylation patterns affect safety and efficacy... more »
    • Small and Smaller
    • Eksigent believes it is unique among significant HPLC vendors in offering micro- and nano-LC instruments only The Eksigent ExpressLC microLC product line uses columns of 3–1  mm ID and either UV detection for pharmaceutical analysis or a mass detector... more »