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April 15, Vol. 29, No. 8

  • Feature Articles

    • Partnerships Strengthen Finland Biotech
    • Susan Aldridge, Ph.D.
    • Finland, particularly the Oulu region, is focused on developing the connections between the life sciences, nanotechnology, and information technology Oulu Bioforum, Oulu Innovation, and other centers in Finland, supported by partners in the German cities of Halle and Leverkeusen, recently ... more »
    • Capitalizing on Fragment-Based Discovery
    • Kathy Liszewski
    • Fragment-based drug discovery is gaining momentum as an efficient strategy to find and optimize leads The technology first identifies small chemical fragments that bind weakly, yet efficiently, to the target, and then grows or combines them to produce a lead ... more »
    • Focused Assays Lead to More Potent Drugs
    • Nina Flanagan
    • The demand for new drugs is pushing companies to develop cell-based assays that focus on a specific cellular event, potentially leading to tailored and more potent therapies These assays also hold promise to predict toxicity, improve extrapolation to humans, and ... more »
    • Fine-Tuning Sample Preparation Techniques
    • Elizabeth Lipp
    • The push toward personalized medicine and the compression of the drug development pipeline puts more pressure than ever on the genome space At CHI’s “Genomics Tools & Technologies” meeting to be held in June, the ever-changing and challenging issues around ... more »
    • Budgets Shifting in Biopharma Manufacturing
    • Eric S. Langer
    • Fear of impending financial calamity can create an environment of cautious budgeting, which can turn into a self-fulfilling prediction In this year’s 6th Annual Report and Survey of Biopharmaceutical Manufacturing, we evaluated the extent to which global manufacturing and vendor ... more »
    • POC Testing Predicted to Transform Healthcare
    • Ian George
    • Recent advances in portable and automated molecular diagnostic systems will address the previously unmet need for decentralized, point-of-care nucleic acid testing Rapid, accurate diagnostic systems suitable for a variety of clinical settings, from the bedside to the battlefield, will enable ... more »
  • Columns

    • Spotlight on the FDA
    • Bruce Mackler
    • In today’s financing environment, the absence of early clinical data presents a high barrier to obtaining funding Investors often say “show me the clinical data that show that the drug is safe and works and I will show you my ... more »
    • Firm Aims to Regulate RNA in Rare Diseases
    • Ilene Schneider
    • When Stuart Peltz, PhD, and Allan Jacobson, PhD, founded PTC Therapeutics in 1998, they realized that post-transcriptional control (PTC) mechanisms—all the regulatory events that take place after an RNA molecule is made—were an unexploited area of biology At the time, ... more »
    • Detection Method for Conformational Change
    • Joshua Salafsky
    • Conformational change of a biomolecule—a change in its structure—is the ultimate basis for signaling in biology A convenient and direct way of detecting structural changes in protein targets, and one that is scalable and requires small amounts of sample, would ... more »
    • Transforming Bioprocessing as We Know It
    • A division of Richmond Chemical, Ingenza uses its biocatalytic processes and engineered enzymes to produce single-isomer chiral intermediates such as unnatural amino acids and chiral amines The company first adapts the enzyme toward the target molecule using solid-phase screening methods ... more »