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March 15, Vol. 29, No. 6

  • Feature Articles

    • Madoff Matters, But Larger Issues Loom
    • Gail Dutton
    • In the months since financier Bernard Madoff was charged with promoting a Ponzi scheme, the financial repercussions continue to ripple Charitable foundations lost millions of dollars, and the recipients of their endowments are feeling the pinch... more »
    • Protein Microarrays See Broader Utilization
    • K. John Morrow Jr.
    • Protein microarrays are one aspect of highly automated, large-scale biological screening technologies, the other is nucleic acid arrays As DNA arrays reveal their origin in Southern blotting protocols, protein microarrays reflect their genesis in Western blotting, in which protein mixtures ... more »
    • U.S. Biofuels Market Off and Running
    • Ellyn Kerr
    • Biofuels are already entrenched in the US transportation fuels market, but not everyone may realize this Yet, according to the Energy Information Association, by the end of 2008, US ethanol facilities were producing up to 668,000 barrels per day (still ... more »
    • miRNA Profiling Opens Doors for New Drugs
    • Nina Flanagan
    • Many key biological processes are impacted by miRNAs, including cell growth and proliferation, tissue differentiation, embryonic development, and apoptosis Mutation, dysfunction, and/or dysregulation of miRNA may lead to diseases like coronary artery disease, cancer, diabetes, AIDS, hepatitis, and obesity, to ... more »
    • Maximizing Value in Outsourcing Services
    • Kathy Liszewski
    • The pharmaceutical industry is, without a doubt, feeling the crunch of skyrocketing costs, lackluster pipelines, and drug safety issues Clinical professionals need to do more with less, while still maintaining the highest levels of quality Many companies are choosing contract ... more »
  • Columns

    • Combating Hospital-Acquired Infections
    • Bruce Carlson
    • Hospital acquired infections (HAIs), also called nosocomial infections to better describe the range of places they can occur, have become a major health concern In the US, between 5% and 10% of patients admitted to acute care hospitals acquire infections ... more »
    • GEN BIO Theater Presentations
    • GEN will sponsor a series of Theater presentations at the BIO Int’l Conference in Atlanta on May 19 and 20 The talks, which will take place at Booth 5807, will provide a venue for visitors in the exhibit hall to ... more »
    • microRNA Expression Profiling of Carcinomas of ...
    • Researchers at Exiqon published an application note describing the use of the company’s miRCURY LNA™ microRNA arrays and Tecan’s HS Pro™ hybridization station for microRNA profiling of carcinomas of unknown primary (CUP) origin The goal of the study was to ... more »
    • Novel OncoMouse Model
    • Caliper Discovery Alliances & Services (CDAS), which offers multiple tumor models for preclinical cancer research, reports that it recently developed a pancreatic OncoMouse® model—EL1-luc/EL1-SV40 T-antigen transgenic—to overcome some disadvantages of xenograft tumor models, such as the use of immuno-compromised mice ... more »
    • China Gains in Innovative R&D
    • In discussing why his company recently opened a 60,000 sq-ft preclinical facility in Shanghai, Chris Perkin, corporate senior vp and president of Canadian and Chinese preclinical services at Charles River Laboratories, notes that China is rapidly “evolving as a center ... more »
  • Tutorials

    • Working with Cryopreserved Hepatocytes
    • Ji Lee
      Timothy Moeller
    • In vitro drug-metabolism data has been increasingly utilized in understanding and predicting pharmacokinetics in vivo Traditionally, predictive studies have been conducted in animal models Because extrapolation from animal to human is difficult due to species differences, attaining human in vitro ... more »
    • Dissecting Protein-Protein Interactions
    • Eric Sundberg
    • Nearly all cellular processes depend on protein-protein interactions Therefore, understanding protein function and protein-protein interactions is key to gaining insights into the biochemical mechanisms that underlie disease and developing new drugs Our current understanding of protein molecular recognition, however, remains ... more »