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February 15, Vol. 29, No. 4

  • Feature Articles

    • Honing In on Targeted Resequencing
    • Kathy Liszewski
    • Targeted resequencing is one of the fastest growing applications for next-generation sequencing technology The ultimate goal is to look for causative mutations within discrete genomic loci in populations in order to enhance diagnostics and treatments The availability of next-generation sequencing ... more »
    • Low-Volume Liquid Handling Gaining Favor
    • Gail Dutton
    • In the unending quest to do more with less, the biotech industry has embraced low-volume liquid handling, and is continuing to advance the tools and techniques that make it a laboratory mainstay With microtiter well volumes often in the nanoliter ... more »
    • Boosting Potential LC/MS Operations
    • Nina Flanagan
    • Although mass spectrometry (MS) dates back to 1897, and high-performance liquid chromatography (LC) to the 1970s, scientists are still developing methods to enhance their capabilities Rapid advancements in the pharmaceutical and biotechnology fields are the main drivers behind new developments ... more »
    • New Antibody Engineering Technologies
    • K. John Morrow Jr.
    • New approaches to antibody engineering were presented at the “European Antibody Congress” held in Geneva, Switzerland last month At the meeting, companies grappled with long-standing issues of glycosylation, antibody structures, alternative structures, and novel purification approaches... more »
  • Columns

    • Recent Advances in NextGen Sequencing
    • Illumina just released new sequencing chemistry kits and complementary software for its Genome Analyzer system These new products reportedly enable researchers to generate 40% more reads per run and extend read length to greater than 75 bp... more »
    • Overreacting to Perceived Risks
    • Henry I. Miller, M.D.
    • From rubber duckies and plastic bottles to pesticides used in agriculture, the world often seems full of lethal hazards Many of these concerns are completely bogus, however, while most of the others represent only de minimis—that is, negligible—risks Moreover, the ... more »
    • PerkinElmer Retools Its Strategic Mission
    • Carol Potera
    • Starting this year, PerkinElmer is aligning its business to focus on two strategic areas—human health and environmental health The new emphasis better defines the strategic mission of the company and, at the same time, improves how it communicates the value ... more »
    • Sky Could Be the Limit for DNA Testing
    • Bruce Carlson
    • DNA testing represents a revolution postponed, perhaps, but one that is now clearly under way After years of glowing predictions that didn’t immediately translate into change in clinical diagnostics, DNA testing has emerged fully from research into clinical practice, and ... more »
    • Executive Interview: Reinhard Vogt, Sartorius St...
    • All industries, including biotechnology, are faced with a drastically different economic environment from that of four or five years ago To get a sense of how a key biotech supplier that operates on a worldwide basis views the current state ... more »