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January 15, Vol. 29, No. 2

  • Columns

    • Capitalizing on Novel Expression Systems
    • Eric S. Langer
    • Over the past decade there has been growing criticism of biopharmaceutical companies as they struggle to increase drug output A new report by BioPlan Associates, “Genetic Expression Systems: Current and Future Manufacturing Platforms,” highlights the slow shift of these companies ... more »
    • GenomeQuest Aims to Streamline Genomics
    • Carol Potera
    • High-throughput, next-generation sequencing instruments have dramatically accelerated the sequencing of genomes They generate huge volumes of data, however, that challenge the limits of current bioinformatic tools and GenomeQuest couldn’t be happier about this predicament The company has developed a high-powered ... more »
    • Minimizing Challenges in Biological Modeling
    • Kristen Zanella
    • Modeling has long played a key role in the drug discovery process, from isolating drug targets to screening and pharmacokinetics Many pharmaceutical companies are currently facing patent expirations without replacement candidates in the pipeline or are struggling with high candidate ... more »
    • Finessing PI3 Kinase Assay Development
    • Kevin Entwistle
    • The EGFR cell-signaling pathway plays a central role in processes such as cell growth, proliferation, survival, and differentiation Understanding the biological role of this pathway and its effect in various cancer types has led to the development of several therapeutic ... more »
    • Shut-off Switch for Cellulose Production Found
    • Scientists at Purdue University say they discovered a mechanism that naturally shuts down cellulose production in plants Learning how to keep that switch turned on may be the key to enhancing biomass production for plant-based biofuels, notes Nicholas Carpita, PhD, ... more »
    • BD Biosciences Expands Capabilities in Cell Cult...
    • While BD Biosciences works toward completing construction of its recently announced animal-free/antibiotic-free (AF2) cell culture media production facility in Miami by the end of the year, the company’s new pilot lab is nearing completion ... more »
  • Tutorials

    • Optimization of Binding Interaction Studies
    • Laura Moriarty, Ph.D.
    • Surface plasmon resonance (SPR) has revolutionized the study of the intricate protein interactions that are required for the execution and maintenance of complex biological processes, enabling the elucidation of the roles that intracellular concentration, ionic environment, cofactors, and protein conformation ... more »
    • Tools for Studying Membrane Protein Targets
    • Christopher Laing
    • Approximately 40% of today’s pharmaceuticals act on proteins such as GPCRs  and ion channels that are embedded within cell membranes These transmembrane proteins form the functional environmental interface of the cell, accounting for their value as therapeutic targets They have ... more »
    • Researchers Tackle Tumors One Cell at a Time
    • Frank Feist
    • Cancer is characterized by genetic heterogeneity that is caused by tumorigenesis Several research groups have begun to measure the degree of genetic heterogeneity in tumors to establish the impact of heterogeneity on cancer diagnostics, prognosis, and selection and monitoring of ... more »