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January 1, Vol. 29, No. 1

  • Feature Articles

    • Linking Disease to Gene Variations
    • Vicki Glaser
    • New technologies and strategies for genetic testing and genomic analysis were the focus of several presentations at the recent American Society of Human Genetics (ASHG) meeting in Philadelphia Understanding the molecular basis of disease, discerning inheritance patterns of genetic disorders, ... more »
    • High-Content Screening Rapidly Evolving
    • David Daniels, Ph.D.
    • Advances in high-content screening (HCS) instrumentation have significantly increased throughput and improved ease of use such that the technology is moving from its traditional role in secondary screening to the earlier stages of the drug-discovery process At the same time, ... more »
    • Exploring the Human Proteome in Depth
    • Elizabeth Lipp
    • Screening technologies for proteins are still gaining momentum, and as the discipline matures scientists are wondering what technologies are best suited for proteomic profiling “There’s also a lot of discussion about quantification methodology—what is the best and most efficient way ... more »
    • Utilization of DNA Microarrays Increasing
    • K. John Morrow Jr.
    • One of the hottest research tools these days within the academic, biotech, and pharma communities is DNA microarrays The concept morphed from the now-classical Southern blotting procedure into the present highly automated systems for screening hundreds of thousands of gene ... more »
    • Peptide Capacity Holding Steady For Now
    • Vicki Glaser
    • Industry sources project a continuing 10 to 15% growth in the market for biotherapeutic peptide new chemical entities, and more modest growth of slightly greater than 10% for generic peptides These projections, however, predate the current global economic downturn and ... more »
    • Stem Cells Continue March Toward Clinic
    • Nina Flanagan
    • Stem cell therapy holds great promise for various diseases In fact, in what many are hailing as a medical milestone, European researchers have successfully transplanted a trachea built from a patient’s own stem cells to replace a failing airway damaged ... more »
    • Korea Lays Groundwork for Future Success
    • Robert Yuan, Ph.D.
    • In a series of recent articles, the restructuring of the global pharmaceutical and biotechnology industry was examined; more specifically, the effect of multinational corporations and Western research institutions, which have invested heavily in major facilities and established key ventures in ... more »
  • Columns

    • Celebrating Charles Darwin in 2009
    • John Sterling
    • This year marks the 200th birthday of Charles Darwin (February 12, 1809) and the 150th anniversary of the publication of the Origin of Species Universities, academic centers, and other scientific organizations all over the globe have a plethora of events ... more »
    • Update on Patent Law Revisions in China
    • Lisa A. Haile
    • The new year will bring many changes and their associated risks and opportunities With President-elect Barack Obama leading the US through one of the murkiest financial times in history, many are looking toward China in the year of Yi Chou, ... more »
    • Sequella Takes On Pernicious Enemies
    • Ilene Schneider
    • Today, about one-third of the world’s population, or two billion people, carry the tuberculosis (TB) bacteria, although most never develop active TB disease Studies estimate that 65 to 70 million people have active TB, there are 8 to 10 million ... more »
    • Fast Growth Foreseen for Protein Therapeutics
    • Andrea Hiller
    • Protein-based therapeutics may be moving from a second-string opportunity to a first-draft prospect The market for protein-based therapeutics is significant and growing at a rate that is well above what one would call average for the therapeutics/pharmaceuticals industry A large ... more »
    • Technology Showcase for New Screening Software
    • A number of HCS vendors will be launching software packages to go along with their instrument portfolios at “High Content Screening’s” Technology Showcase According to Mark Collins, marketing manager for cellular imaging at Thermo Fisher Scientific, the focus in the ... more »
  • Tutorials

    • Tritiated Opiate Receptor Radioligands
    • Crist Filer
    • The alleviation of pain is perhaps the greatest long-standing goal of both ancient and modern medicine Quite recently, opiate receptors were implicated in the propagation of pain With exquisite complimentary molecular architecture, these protein pockets tightly bind smaller endogenous molecules, ... more »
    • Impact of Ultrafiltration of Hydrolysates
    • Tobi Limke
    • Hydrolysates (peptones) are widely used in biopharmaceutical manufacturing to enhance cellular growth and production Ultrafiltration is often utilized to remove large molecular weight entities including endotoxin from hydrolysates While minimization of endotoxin is a high priority in biomanufacturing, the necessity ... more »