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May 15, Vol. 37, No. 10
  • Feature Articles

    • Machines Learn to Sift Big Biodata
    • Kristen Slawinski
    • Biodata gold is all around us, but it is hard to find, distributed as it is in traces throughout a vast biodata landscape, one that has scarcely been explored properly, even as it continues to be reshaped by next-generation sequencing, ... more »
    • Biomarker Validation for Genomic Assays
    • Lisa Heiden
    • Pity the genomic scientist who specializes in biomarker development, a discipline that is still being built around next-generation sequencing (NGS) This new discipline, which could be called next-generation molecular diagnostic assay validation, is currently grappling with a range of challenges: ... more »
    • Liquid Biopsies Remain Wait and See for Some Cli...
    • Clinicians are starting to become aware of the advantages of liquid biopsy, but they still have reservations The point is, clinicians are unlikely to be moved by superficial appeals to technological progress They will not fully accept liquid biopsy until ... more »
  • Columns

    • Insights
    • Abbott Laboratories and Alere have good reason to expect their long-planned merger to be completed by the third quarter as announced, following an agreement that revises key pieces of the deal... more »
    • SpaceX-Style Gene Editing Achieves Liftoff
    • Gail Dutton
    • Synthego is applying the Agile development methods and entrepreneurial lessons its founders learned at SpaceX to biotech, with the eventual goal of developing a virtual cloud laboratory offering biology as a service Its flagship product, CRISPRevolution, is the first step ... more »
    • Automatic Piston Discharge Pushes Ahead
    • Formerly known as Celeros Separations, Inc (Foxborough, MA), Celeros Separations, LLC (Durham, NC) has been acquired by its founder Robert Bret Carr, and is now under new ownership and management as of January 2017 Celeros Separations (wwwceleros-separationscom) has re-launched and ... more »
    • Advertorial: OmniAb
    • Antibodies offer several favorable characteristics such as high specificity, minimal off-target effects and good safety profiles By triggering several immune effector mechanisms, antibodies can effectively neutralize pathogens, inactivate target antigens or destroy malignant cells In addition, because antibody manufacturing follows ... more »
  • Tutorials

    • Monitor the Activity of Any Methyltransferase
    • Said A Goueli
    • Methylation is a key post-translational modification (PTM) of mammalian proteins and nucleic acids where unique enzymes known as methyltransferases (MTases) transfer methyl groups to a variety of nucleophiles (eg, oxygen, carbohydrates, nucleic acids, small molecules, and carbon atoms on proteins)... more »