Sensitivity Gains Enable New Applications on Triple Quadrupole and Q-TOF Instruments with iFunnel Technology

• Broadcast Date: Thursday, December 1, 2011
• Time: 11:00 am EST / 8:00 am PST

REGISTRATION IS FREE

AVAILABLE ON DEMAND

Significant gains in LC/MS performance require a fundamental rethinking of atmospheric ion creation and sampling. This webinar introduces iFunnel Technology, which creates and samples many more ions to allow low ppt detection levels and sub-ppm quantitation levels for mass spectrometric analysis of compounds in a matrix. iFunnel Technology has been incorporated into Agilent Triple Quadrupole and Quadrupole Time-of-Flight (Q-TOF) mass spectrometers to afford low levels of sensitivity and robust operation.

Participants in this webinar will discuss the theoretical basis for iFunnel development and design that have allowed its successful use with mass spectrometers. The increased sensitivity directly impacts the detection and quantitation of compounds in diverse application areas including: 1) pharmaceutical research, including metabolic stability, and metabolite ID and profiling, and 2) proteomics, showing the use of increased sensitivity
to allow better protein identification and quantitation.

What You Will Learn in This Webinar

• How iFunnel technology facilitates Qual/Quan workflow for simultaneous determination of metabolic stability, and metabolite ID and profiling utilizing accurate mass measurements
• How sensitivity gains from iFunnel technology on the Agilent 6490 Triple Quadrupole allow conversion from nanoflow to normal flow chromatography for high sensitivity applications to improve assay robustness
• How a method for a multiplex cardiovascular disease assay can achieve sensitivity down to 2 ng protein/mL, with technical and analytical reproducibility

Who Should Attend

• Analytical chemists who require the highest levels of LC/MS sensitivity
• Analytical chemists using LC/MS to quantify small molecules, peptides, or proteins
• Drug development scientists
• Biomarker and proteomics scientists
• Mass spectrometrists

Panelists Include

• George Stafford, Ph.D., Director of LC/MS R&D Hardware, LC/MS Division, Agilent Technologies
• Christoph Borchers, Ph.D., Professor, University of Victoria, Director of Genome BC Proteomics Centre, CSO of MRM Proteomics
• Christian Klein, Ph.D., Analytical Chemist, Agilent Technologies

John Sterling, Editor in Chief, Genetic Engineering & Biotechnology News, will be the host of this webinar. A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists.

AVAILABLE ON DEMAND