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PODCAST: Archived Interview (January 15, 2009)

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INTERVIEW: NOVEL GLIOBLASTOMA MOUSE MODEL - Interview with Inder Verma, Ph.D., Professor, Laboratory of Genetics, Salk Institute for Biological Studies

Researchers at the Salk Institute for Biological Studies have developed a versatile mouse model of glioblastoma that closely resembles the development and progression of human brain tumors that arise naturally.

During this week's podcast, Dr. Inder Verma discusses what makes his mouse model system so novel and how it differs from other animal models for studying cancer. He also explains how this model avoids the limitations of other currently used cancer models and why he specifically targeted astrocytes with lentiviral vectors.

The Salk research study was based on the cancer stem cell hypothesis, which posits that cancers grow from stem cells in the same way healthy tissues do. Dr. Verma details how his group carried out tests to see if the induced glioblastomas in his mouse model actually contained bona fide cancer stem cells. He also looks at new avenues of research on cancer that might now open up as a result of his animal studies.

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