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PODCAST: Archived Interview (December 24, 2008)

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INTERVIEW: X FILES OF BIOLOGY - LARGE-SCALE GENE SILENCING MYSTERY SOLVED - Interview with Craig Pikaard, Ph.D., Professor of Biology, Washington University in St. Louis

A research team from Washington University in St. Louis says it has made a major advance in understanding the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes in a hybrid plant or animal. They published their results in Molecular Cell on December 4.

Since the machinery involved in nucleolar dominance is some of the same that can go haywire in diseases such as cancer, the scientists believe their work may have important applications in a number of areas. Although biologists have been studying nucleolar dominance since the 1920s, this phenomenon remained largely unresolved until recently, when Dr. Craig Pikaard's lab reversed an old dogma.

During this week's podcast, Dr. Pikaard discusses the involvement of ribosomal RNA in nucleolar dominanace. He also addresses the issue of what dogma his group overturned through its research project and provides specific details on the major implications of the research study for applied medical research.

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breakthrough

by: mustapha opeyemi

12/29/2008

it was another breakthrough in the study of genetics.More of such should be encouraged


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