Current Issue

View Larger Image

Past Issues Adlink Subscription Visit Our Publisher

Top Keywords

GEN podcasts

*Podcasts play in a pop-up window. Please make sure your pop-up blocker is off.

GEN’s editor in chief, John Sterling, interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

STUDYING PROTEIN FOLDING AND DYNAMICS IN LIVING CELLS

5/14/2010

-Interview with Martin Gruebele, Ph.D., James R. Eiszner Professor of Chemistry at the University of Illinois at Urbana-Champaign

Researchers at the University of Illinois at Urbana-Champaign have created a novel technique for studying protein dynamics in living cells. Evidence yielded from the new approach indicates that an in vivo environment strongly modulates a protein’s stability and folding rate, according to the scientists. During this week’s podcast Dr. Martin Gruebele talks about how the method that he and his team of co-researchers engineered marks the first time that anyone has been able to follow the real-time folding and unfolding of proteins outside of a test tube. He refers to the development of a hybrid technique called “Fast Relaxation Imaging,” which combines fluorescence microscopy and fast temperature jumps. It was used to study the bimolecular dynamics inside a single living cell. Since bimolecular dynamics are predominantly studied in vitro, with the results extrapolated to explain how the same processes would function in a living cell, Dr. Gruebele explains how the new technique has yielded data that could change some standard thinking in the field of molecular biology. He also discusses the application of Fast Relaxation Imaging to the study of neurological disorders that cause dementia such as Alzheimer, Huntington, and Creutzfeldt–Jakob disease.

Dr. Martin Gruebele received his B.S. degree in 1984 and his Ph.D. in 1988 from the University of California at Berkeley. After working as a postdoctoral fellow at the California Institute of Technology, he joined the faculty of the University of Illinois in 1992. Dr. Gruebele is also a faculty member of the Beckman Institute.

Subscription center

GEN MAGAZINE
	Genetic Engineering & Biotechnology News (GEN) has retained its position as the most widely read biotechnology publication around the globe since its launch in 1981. Published 21 times a year and with additional exclusive editorial content online, GEN's unique news and technology focus includes the entire bioproduct life cycle from early-stage R&D, to applied research including omics, biomarkers, as well as diagnostics, to bioprocessing and commercialization. Subscribe

e-NEWSLETTERS
Add GEN to your Inbox! Subscribe today to our complimentary e-newsletters and stay abreast of the latest biotech news and trends. Click the magnifying glass icon next to a newsletter title to view a sample.
GEN Daily News Highlights - provides succinct and timely biotech news on the entire biotech field. GEN News Highlights of the Week - showcases the week's top biotech news. GEN Table of Contents (TOC) Alert - This alert provides a sneak peak at the latest issue of GEN. GEN Tech Focus - is published monthly to provide the latest advances in biotech's hottest topics. GEN Biotech Events - a weekly newsletter featuring webinars, meetings, and conferences. GEN New Products Watch - a monthly summary of products and services by tool providers. New product information and special offers from select biotech suppliers.
	All fields are required
Email
Confirm Email
First Name
Last Name
Organization
E-Alert Format


	Sign Up