Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN Podcasts

*Podcasts play in a pop-up window. Please make sure your pop-up blocker is off.

GEN’s editorial staff interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

A large number of illnesses stem from misfolded proteins. Researchers at the University of Zurich have now studied protein misfolding using a special spectroscopic technique. Misfolding, as they report in a recent issue of Nature, is more frequent if the sequence of the amino acids in the neighboring protein domains is very similar.

During this week’s podcast one of the Nature paper’s authors, Dr. Benjamin Schuler, provides specific examples of diseases that result from problems in protein folding and discusses how he and his team went about investigating the circumstances under which protein misfolding occurs. He describes the type of technology the group used to carry out the research project and reveals the team’s major findings.

Dr. Schuler also talks about the clinical implications of the work on protein misfolding and highlights future laboratory projects designed to take this research to the next level.

Ben Schuler joined the department of Chemistry at the University of Zurich in 2004 and was promoted to full professor of biochemistry in September 2009. He investigates the folding, misfolding, and dynamics of proteins using a close combination of biochemical and spectroscopic methods, in particular single-molecule fluorescence. Dr. Schuler studied biochemistry at the University of Regensburg, Germany, and at the University of Kent, U.K. He received his Ph.D. in physical biochemistry from the University of Regensburg in 1998. He did his postdoctoral research in biophysics at the NIH. Supported by the Emmy Noether Program of the Deutsche Forschungsgemeinschaft, Ben Schuler then headed an independent research group at the University of Potsdam in Germany.

  • Add a comment

  • Click here to Login/Register for free. You will be taken back to your selected item after Login/Registration.

Related content

Be sure to take the GEN Poll

Cancer vs. Zika: What Worries You Most?

While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country’s most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?

More »