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GEN’s editor in chief, John Sterling, interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

NOVEL RETRIEVAL METHOD FOR STUDYING CANCER PROTEINS

7/16/2010

Interview with W. Andy Tao, Ph.D., Assistant Professor, Analytical Chemistry and Chemical Biology, Purdue University

A Purdue University researcher says he can better retrieve specific proteins needed to study how cancer cells form by using a newly developed technique and a synthetic nanopolymer. Dr. W. Andy Tao notes that while such phosphoproteins can be mapped and analyzed to find ways to inhibit the processes that lead to cancer those few proteins first must be fished out of a sea of thousands of other proteins.

During this week’s podcast Dr. Tao discusses his polymer-based metal-ion affinity capture method for retrieving phosphoproteins. He talks about studies that have demonstrated the usefulness of the technique and points out its advantages over other methods for working with phosphoproteins.

Dr. Tao also looks at other applications for the novel methodology and tells GEN about future plans for his team’s research.

Dr. W. Andy Tao received his Ph.D. education in Professor R. Graham Cooks’ premier mass spectrometry group in 2001 and postdoctoral training in systems biology in Professors Leroy Hood and Ruedi Aebersold’s groups from 2002–2004. He is currently an associate professor in the departments of biochemistry, chemistry, and medicinal chemistry & molecular pharmacology at Purdue University. His research group has focused on mass spectrometry-based proteomic research and, in particular, has pioneered the development of soluble nanopolymers as a novel platform for protein modifications at the proteome scale.

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