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GEN’s editor in chief, John Sterling, interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

NANOTECHNOLOGISTS CREATE ARTIFICIAL PORE

11/5/2009

- Interview with Peixuan Guo, Ph.D., Director of the NIH Nanomedicine Development Center at the University of Cincinnati, Endowed Chair, and Professor of Biomedical Engineering

Using an RNA-powered nanomotor, University of Cincinnati (UC) biomedical engineering scientists successfully developed an artificial pore able to transmit nanoscale material through a membrane.

In a study led by Dr. Peixuan Guo, members of the UC team inserted the modified core of a nanomotor into a lipid membrane. The resulting channel enabled them to move both single- and double-stranded DNA through the membrane.

During this week's podcast Dr. Guo talks about the creation of the RNA nanomotor and provides additional details on how it was used and on the results that were obtained. He discusses the key differences between the UC team’s single pore construct and other systems and explains the importance of such differences.

Dr. Guo goes on to explore the potential use of the engineered biopore channel and looks at some of the broader applications of the method by which the scientists were able to move DNA through the membrane.

Peixuan Guo, PhD, is the Director of the NIH Nanomedicine Development Center at the University of Cincinnati, one of eight Nanomedicine Development Centers in the country. At UC, he holds the Dane and Mary Louise Miller Endowed Chair in Biomedical Engineering and serves as a professor in the biomedical engineering department. Guo received his PhD in Microbiology & Genetics at the University of Minnesota and completed postdoctoral work in Molecular Virology at New York State Department of Health as well as serving as a visiting scientist at the NIH. Currently, Dr. Guo is a member of the NIH Steering Committee and serves as an editor/editorial board member for four nanotech journals. His research concentrates on nanobiotechnology, specifically RNA nanotechnology.

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