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MOLECULE FOR REGULATING HEART SIZE DISCOVERED

8/13/2009

- Interview with Michael Tsang, Ph.D., Assistant Professor, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine

Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. The findings were described online in Nature Chemical Biology on July 5.


During this week's podcast Dr. Michael Tsang takes a close look at the key findings of the research group and talks about the main implications of the study for research on the heart. He also discusses why the zebrafish was a good model for this work.


While the discovery is particularly relevant for cardiology, Dr. Tsang goes onto to explain the importance of the study for wound healing as well. He also provides details on plans for future experiments that are designed to move this research forward.
Michael Tsang, Ph.D., has been an assistant professor in the Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, since 2004 and a member of the university's Drug Discovery Institute since 2008. His research focuses on understanding the developing embryo, primarily through study of zebrafish, vertebrates whose transparent embryos are carried outside the mother. Dr. Tsang completed his postdoctoral training at the National Institute of Child Health and Human Development. He received his doctorate in 1996 and his Bachelor of Science (Hons.) in pharmacology in 1992 from University College Dublin, Ireland.

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