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GEN’s editor in chief, John Sterling, interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

miRNAs AND CANCER

4/17/2008

- Interview with George Calin, M.D., Ph.D., Associate Professor, Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center

KEYWORDS:
Cancer
,
miRNA

The association between miRNAs and cancer has become one of the most intense areas of interest in biomedicine. Key goals are to help determine the prognosis of a cancer patient once diagnosed and develop the most promising course of therapy.

During this week's GEN podcast, Dr. George Calin from M. D. Anderson provides additional details on why work on miRNAs has become such a hotbed of research activity in the life sciences. He notes the evidence of a significant role for miRNAs in cancer and discusses what he and his team call the "main paradigms" for the involvement of miRNAs in human cancers.

Dr. Calin also talks about the importance of genome-wide profiling in miRNA research and offers examples of how miRNA arrays and quantitative RT-PCR technologies are used in such genome-wide profiling studies. In addition, he explains the theoretical rationale for using miRNAs in cancer treatment.

George Adrian Calin received both his M.D. and Ph.D. degrees at Carol Davila University of Medicine in Bucharest, Romania. After working cytogenetics as undergraduate student with Dr. Dragos Stefanescu in Bucharest, he completed a cancer genomics training in Dr. Massimo Negrini’s laboratory at University of Ferrara, Italy. In 2000 he became a postdoctoral fellow at Kimmel Cancer Center in Philadelphia, PA, in Dr. Carlo Croce’s laboratory. He is presently an Associate Professor in Experimental Therapeutics at MDACC and studies the roles of microRNAs and other non-coding RNAs in cancer initiation and progression, as well as the mechanisms of cancer predisposition and explores new RNA therapeutic options for cancer patients.

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