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GEN’s editor in chief, John Sterling, interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

A team at The Scripps Research Institute reports that it has made major strides in solving a problem that has been plaguing chemists for many years: how best to break carbon-hydrogen bonds and then to create new bonds to join molecules together. This problem is of great importance to the pharmaceutical industry, which currently relies on a method to accomplish this feat that is relatively inefficient and sometimes difficult to perform.

The research was published online on November 26, 2009, in Science Express.

During this week's podcast, team leader Dr. Jin-Quan Yu provides additional details on the pharmaceutical industry's interest in carbon-hydrogen bonds. He discusses the advantages, and the downside, of relying on the "Mizoroki-Heck" reaction, which is currently used by chemists and pharmaceutical scientists to forge carbon-carbon bonds in place of carbon-hydrogen bonds.

Dr. Yu goes on to describe the new technique his team developed to break carbon-hydrogen bonds more efficiently and economically and how it might impact the discovery, development, and manufacture of novel drug compounds.
Jin-Quan Yu, Ph.D. is an Associate Professor in the Department of Chemistry at the Scripps Research Institute.

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