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GEN’s editorial staff interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

Scientists from the Scripps Research Institute have discovered a catalytic antibody that degrades a known appetite stimulant. The antibody works against the gastric hormone ghrelin, which has been linked to weight gain and fat storage through its metabolic actions. These findings point toward a potentially novel treatment for obesity that would interfere directly with some of the biological mechanisms determining weight, according to the researchers.

During this week's podcast, Scripps' Dr. Kim Janda outlines his team's antibody experiment and talks about the research results in mice. He explains why the new approach, called passive immunopharmacotherapy, might eventually be a promising method for treating obesity in people.
Kim Janda, Ph.D.Ely R. Callaway, Jr. Professor of Chemistry PROFESSOR Director, Worm Institute of Research & Medicine (WIRM) Department of Chemistry TSRI - 1985 Joint Appointments Immunology The Skaggs Institute for Chemical Biology Education B.S., University of South Florida, 1980 M.S., University of Arizona, 1983 Ph.D., University of Arizona, 1984 Awards & Activities Arthur C. Cope Scholar Award 1999; NIH First Award 1990-1995 Alfred P. Sloan Fellowship 1993-1995 University of South Florida Outstanding Alumnus in Chemistry 2001 J. Clarence Karcher Lecturer, University of Oklahoma, Norman, Oklahoma Alumni of the Year, University of South Florida, Tampa, Florida Editorial Boards: Chemical Reviews, Combinatorial Chemistry Research and Applications, Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry, Combinatorial Chemistry High-Throughput Screening. Scientific Advisory Boards: Acidophil LLC, Aventis Pharmaceuticals, Chembiotek Research International, Dihedron LLC, Materia Inc., Joint Scientific Council Committee, Novartis/TSRI. Steering committees: Novartis/TSRI.

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