Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Dec 9, 2010

Zealand Pharma Gets €500K Milestone Fee from Helsinn Healthcare

  • Zealand Pharma received a €500,000 (about DKK 3.73 million) milestone payment as part of its license agreement with Helsinn Healthcare for ZP1846 in chemotherapy-induced diarrhea. The firm has received €10 million in milestones, including today’s fee, from Helsinn under its November 2008 agreement.

    Helsinn Healthcare received a worldwide, exclusive license and assumed responsibility for all further development, regulatory approvals, manufacturing, marketing, and sales of ZP1846. Total development and sales-based milestone fees due to Zealand Pharma are €140 million. Zealand will also receive a royalty on sales and has an option to sales and marketing rights for the Nordic countries.

    ZP1846 is a glucagon-like-peptide-2 (GLP-2) analog. GLP-2 is a naturally occurring peptide hormone produced primarily by the small intestine. It is secreted in response to food ingestion and acts by binding to the GLP-2 receptor, which is predominantly found in the gastrointestinal tract.

    GLP-2 plays a key role in intestinal growth and formation by promoting regeneration of the epithelial surface that is damaged by chemotherapy, the underlying cause of chemotherapy-induced diarrhea, the firm explains. Helsinn Healthcare recently initiated a Phase Ib trial in five centers in Europe involving colorectal cancer patients following the completion of a Phase Ia clinical study of ZP1846 by Zealand Pharma in the U.S.

    Zealand has another GLP-2 compound, ZP1848, in clinical development for the treatment of Crohn disease. A Phase Ia single-dose study in healthy volunteers and a Phase Ib multiple-dose study in patients in the U.S. were completed this year. The firm expects to initiate a Phase IIa trial by the first quarter of 2012.



Related content

Be sure to take the GEN Poll

Drug Price Hikes

Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?

More »