Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Jun 8, 2010

Zealand Pharma and Sanofi-Aventis Expand Type 2 Diabetes-Focused Partnership

  • Zealand Pharma reports that its global licensing agreement with sanofi-aventis has been amended to provide for the development and commercialization of Lixisenatide in combination with Lantus®, sanofi-aventis’ recombinant human insulin analog. The original arrangement covered Lixisenatide alone and comprised nineclinical studies within the GetGoal Phase III program, which began in May 2008.

    Lixisenatide, discovered at Zealand, is a GLP-1 (glucagon-like-peptide-1) receptor agonist for the treatment of type 2 diabetes. It uses Zealand’s SIP™ (structure inducing probe) peptide-modification technology. Lantus is sanofi-aventis’ number one brand with 2009 sales of more than €3 billion, according to Zealand. Phase III investigations for the Lantus plus Lixisenatide regimen is expected to commence later this year.

    In April sanofi-aventis reported positive Phase III results from the first trial  within the GetGoal program. NDA filing of Lixisenatide is expected to take place in the second quarter of 2011 in Europe and the second quarter of 2012 in the U.S.

    The companies restructured the financial terms of the agreement to provide Zealand with payments for the achievement of development, regulatory, and sales milestones for the Lantus + Lixisenatide combination product. Royalties to Zealand for Lixisenatide and the Lantus + Lixisenatide combination product as well as other nondisclosed provisions of the agreement were also revised, although details were not disclosed.



Related content

Be sure to take the GEN Poll

Cancer vs. Zika: What Worries You Most?

While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country’s most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?

More »