Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Sep 30, 2010

ThromboGenics Taps MSD for Long-Term Commercial Supply of Microplasmin

  • ThromboGenics signed a 10-year supply agreement with MSD Biologics, part of the Merck BioManufacturing Network for the production of microplasmin. ThromboGenics anticipates that this deal will meet its long-term commercial needs for bulk drug substance.

    Microplasmin, which is ThromboGenics’ lead drug candidate, recently completed two successful Phase III trials in patients with vitreomacular adhesion (VMA). ThromboGenics is targeting for BLA and MAA submissions by mid 2011.

    MSD Biologics, a contract manufacturing organization with specific expertise in microbial-derived biologics, has been producing microplasmin for ThromboGenics since 2007. It provided the clinical bulk substance for ThromboGenics’ Phase III program, which recruited over 650 patients in the U.S. and Europe.

    MSD Biologics will produce microplasmin at its Billingham, U.K., facility, which has been approved for commercial production by both the FDA and the EMEA. Microplasmin is a truncated form of the natural human protein plasmin. ThromboGenics has reportedly created the first stabilized and readily manufactured form of this molecule.

Related content

Be sure to take the GEN Poll

Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

More »