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Jul 15, 2014

Thermo Fisher Unveils New HPLC System

Thermo Fisher Unveils New HPLC System

The Thermo Scientific Vanquish UHPLC system.

  • Thermo Fisher Scientific introduced a new high-performance liquid chromatography system that can be used as a standalone or with the latest mass spectrometers. According to a company official, the Vanquish UHPLC looks different from standard UHPLC systems, standing about 25% lower than comparable modular stacks, noted Fraser McLeod, vp and general manager, HPLC, Thermo Fisher Scientific.

    “Rather than making incremental improvements to UHPLC, Thermo Fisher Scientific has designed this system from the ground up. The result is a system that combines advantages in separations performance, sample throughput, ease-of-use, reproducibility, and method transfer efficiency,” explained McLeod.

    Central to the Vanquish concept is the new family of Thermo Scientific Accucore Vanquish UHPLC columns, specially designed to optimize performance, he added. “The new columns feature 1.5 µm solid core particles utilizing Core Enhanced Technology to take full advantage of the Vanquish system’s 1,500 bar (22,000 psi) maximum pump pressure and flow rate up to 5 mL/min for ultra-short diffusion path lengths and highly efficient separations,” continued McLeod.

    Other features include:

    • SmartFlow pumping technology designed for reproducible retention times  and low baseline noise to enhance detection sensitivity;
    • Temperature control capabilities, including direct heating and forced air temperature control modules in the column compartment, to enhance separation efficiency and selectivity, as well as retention time reproducibility;
    • An insulated autosampler compartment with new air-to-air cooling, which reportedly protects vials from water condensation (even in hot and humid environments);
    • The Thermo Scientific Dionex Chromeleon chromatography data system, which was designed to calibrate the system automatically and unattended. eWorkflow and Intelligent Run Control automation are included to enhance data quality and instrument efficiency
    • Optional handheld tablet lets users monitor system status, check runs, and make changes.


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