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July 17, 2008

Thermo Fisher Scientific MS Tools Used by Harvard University to Identify Proteins in Cancer Pathways and Dinosaur Fossils

  • Researchers at Harvard Medical School say they are using a range of  Thermo Fisher Scientific’s mass spectrometry instrumentation for targeted proteomics applications.

    John M. Asara, Ph.D., director of the mass spectrometry core facility at the Beth Israel Deaconess Medical Center (BIDMC) and colleagues have used a Thermo Scientific LTQ™ linear ion trap and LTQ Orbitrap XL™ to develop proteomics-based strategies for identifying novel signaling proteins and modifications of functional significance to cancer pathways.

    These techniques have also been applicable to his work on fossilomics (the analysis of fossil bone proteins from extinct organisms). Along with scientists from North Carolina State University, Dr.  Asara has extracted and sequenced tiny pieces of collagen protein from dinosaurs. The sequences from a 68 million year old Tyrannosaurus Rex and a 160,000–600,000 year old mastodon are the oldest to ever be reported. The researchers proposed a link between the T. rex and current day chickens and the mastodon with modern elephants.

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