Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Jul 27, 2010

The Leukemia & Lymphoma Society to Provide Shape Pharmaceuticals with $3.3M

  • The Leukemia & Lymphoma Society (LLS) and Shape Pharmaceuticals entered into a partnership to advance the firm’s topical treatment for cutaneous T-cell lymphoma (CTCL) into clinical development. LLS will provide up to $3.3 million through its Therapy Acceleration Program (TAP) to support the remaining preclinical studies needed for an IND and a Phase Ib study.

    The compound, SHP-141, was discovered by LLS-funded researcher James Bradner, M.D., of Dana-Farber Cancer Institute, and Ralph Mazitschek, Ph.D., of Massachusetts General Hospital. Drs. Bradner and Mazitschek founded Shape in 2008 with funding and management from HealthCare Ventures.

    SHP-141 is a small molecule, histone deacetylase inhibitor designed to result in activity directly on the skin without systemic exposure. By limiting systemic toxicity, SHP-141 has potential for application during the protracted early stages of CTCL in addition to during late-stage disease as part of a combination therapy. The clinical trial is expected to enroll patients in early 2011.

Related content

Be sure to take the GEN Poll

Drug Price Hikes

Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?

More »