GEN Exclusives

More »

GEN News Highlights

More »
Mar 10, 2014

Takeda, UCL Partner in $250K Study of Treating MD with iPS Cells

  • Takeda and University College London (UCL) will partner on research into muscular disorders, specifically the potential for induced pluripotent (iPS) stem cells to treat muscular dystrophy.

    A research group led by Francesco Saverio Tedesco, M.D., Ph.D., will assess whether the iPS cells will enable production of large quantities of progenitor cells that can be transplanted into a patient's muscle following genetic correction, or as part of drug development platforms.

    Dr. Tedesco’s team will also investigate the potential for treating muscular dystrophy through new gene and cell therapy strategies using artificial human chromosomes and novel biomaterials.

    The research will be funded with $250,000 from Takeda’s New Frontier Sciences group, designed to support research that could eventually lead to drug discovery and development. “With Takeda's backing, my team and I will be building on the processes we've already shown to be promising and which could pave the way for the development of novel strategies for both cell therapies and drug discovery in muscle disorders," Dr. Tedesco said in a statement.

    Through previous work using a mouse model of Duchenne muscular dystrophy, Dr. Tedesco and colleagues in 2011 showed the potential of preclinical gene replacement therapy using an artificial human chromosome. A year later in a separate study, Dr. Tedesco and his team demonstrated the potential of genetically corrected iPS cells transplanted into another mouse model of a genetic muscle disorder, limb-girdle muscular dystrophy 2D.

    "That several different strands of their research have already borne fruit was strong evidence for us of the translational potential of Dr Tedesco's research for muscular dystrophies," added Gordon Wong, D.Phil., Head of New Frontier Science at Takeda.



Related content

Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

New Drugs for Ebola

Do you think that biopharma companies should not have to go through the normal drug approval process in order to get potential life-saving therapies to Ebola patients more quickly?