Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Jan 11, 2011

Takeda Pays Zinfandel $9M Up Front for Rights to Predictive AD Biomarker

  • Takeda Pharmaceutical is paying Zinfandel Pharmaceutical $9 million up front for a worldwide license to the latter’s Tomm40 biomarker assay, which is in development for use in predicting the five-year risk of Alzheimer’s disease in high-risk older adults. The firms will work together to prospectively validate the Tomm40 biomarker as a test of individual risk, and in particular in patients receiving pioglitazone, the active ingredient in Takeda’s marketed type 2 diabetes drug Actos®. Over the last few years pioglitazone has been debated as a potential therapy for Alzheimer disease.

    Under terms of the agreement with Zinfandel Takeda has an exclusive license to the Tomm40 assay along with sublicensing rights for applications including identifying high-risk older adults eligible for clinical trials with pioglitazone. Zinfandel could receive up to $78 million in development milestones on top of the initial signing fee, plus commercial milestones and sales royalties. The firm was established to develop the Tomm40 biomarker, which was discovered by a team led by Allen Roses, M.D., Zinfandel’s CEO.

Related content


GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

What Does Brexit Mean for Biotech?

Do you agree with the contention that Brexit will NOT have a long-term negative impact on the British biotech industry?

More »