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Patterning of embryonic stem cells in culture has been achieved by geometric confinement. The cells shown here segregated into endoderm (red), mesoderm (blue), and ectoderm (black) 48 hours after they started to differentiate. [Rockefeller University]
During embryonic development, stem cells not only differentiate, they start to organize themselves. Rather than merely clumping, they form a distinctly layered structure. Actually, ...
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