GEN Exclusives

More »

GEN News Highlights

More »
Jun 21, 2010

Skyline Diagnostics to Leverage TrovaGene NPM1 Technology in AML Diagnostic

  • Skyline Diagnostics licensed TrovaGene’s NPM1 technology for addition to its AMLprofiler™ microarray, an in vitro diagnostic for acute myeloid leukemia (AML). Skyline Diagnostics plans to initially offer this product as a laboratory testing service in Europe and will eventually expand to markets outside of Europe.

    AML is a cancer of the bone marrow in which the rapid proliferation of abnormal cells interferes with normal blood cell production. The nucleophosmin protein mutation is found in approximately 35% of AML patients and occurs in 50–60% of AML patients with normal karyotypes, according to Skyline.

    The NPM1 mutation status is associated with good disease prognosis. The NPM1 mutation is also used as a patient-specific biomarker for monitoring minimal residual disease and early detection of recurrence after treatment, the companies add.

    The AMLprofiler in vitro diagnostic test replaces nine separate assays, combining cytogenetics, mutation analysis, and expression analysis in a single three-day microarray-based test. With the AMLprofiler more than 50% of the intermediate risk group of AML patients can be reclassified into either the favorable or the unfavorable risk group, according to Skyline Diagnostics.

    With its headquarters and product development in San Diego, TrovaGene has focused on developing tests using its patented transrenal nucleic acid technology. Transrenal DNA (Tr-DNA) and RNA (Tr-RNA) are short nucleic acid fragments from normal cell death that cross the kidney barrier and can be detected in urine.

    Skyline Diagnostics develops and markets array-based diagnostic tests using gene signatures for personalized medicine in oncology. Its products, called Profilers, are based on gene expression and provide insight on the prognosis of individual patients.

Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

Patient Access to Genetic Information

Do you think patients have the absolute right to gain access to their own genetic information from medical or clinical laboratories?

More »