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Nov 3, 2009

Sigma-Aldrich Licenses Polyplus Transfection’s ZNA Oligos for Research Use

  • Sigma-Aldrich negotiated a worldwide license agreement to manufacture and commercialize Polyplus-transfection’s Zip Nucleic Acid (ZNA™) oligonucleotides for research applications. The company points out it will be the first to offer ZNA as custom DNA and RNA oligos to the life science industry.

    ZNA’s are oligonucleotides with attached cationic units. Polyplus claims the cationic residues increases the sensitivity of the oligos and results in increased affinity for nucleic acids without the loss of selectivity. Research applications of ZNAs include their use as PCR probes and primers, for in vitro miRNA detection and inhibition, and for siRNA applications.



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While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country’s most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?

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