Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Dec 10, 2010

Serodus Licenses Potential Heart Failure Therapy from Roche

  • Serodus has licensed a selective serotonin-4 (5-HT4) antagonist called RO1160367 from Roche for the treatment of heart failure. The molecule is reportedly ready to enter Phase II studies.

    Under the agreement Serodus will receive the full preclinical and clinical documentation for RO1160367, which will be called SER101. In return, Roche will get an up-front payment as well as be entitled to development, regulatory, and commercial milestone fees. Roche is also eligible to receive royalties on sales of products commercialized under the license.

    Serodus has been granted the exclusive development, manufacturing, and worldwide marketing and sale rights. The firm is allowed to sublicense the drug, and, in certain cases, Roche has the right to regain the product.

    Researchers at the University of Oslo discovered that muscle cells in failing cardiac ventricles express 5-HT4 receptors as a response to this condition. The effect of 5-HT4antagonists in heart failure has been demonstrated in rat and man, according to Roche and Serodus.

    Remarking on the in-licensing, Eva Steiness, M.D., Serodus CEO, says, “This agreement will enable Serodus to move its heart failure program directly into the clinic without waiting for our own preclinical development.”

    Serodus has one other clinical-stage compound and a preclinical candidate, SER102, for postsurgical atrial fibrillation. SER100 is an opioid-1 that was acquired from Zealand Pharma this year. The results from previous studies in chronic and acute heart failure indicate that the drug has potential to treat isolated systolic hypertension, which Serodus will pursue in a Phase IIa trial.

Related content

Be sure to take the GEN Poll

Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

More »