Two papers in Nature Genetics report the identification of separate mutations involved in rheumatoid arthritis (RA) that are both on the same region of chromosome 6.
Researchers from Brigham and Women’s Hospital and The Broad Institute carried out a genome wide association study of nearly 400 individuals with RA and identified a novel variant, rs10499194, that maps to 6q23 and increases the risk of developing the disease.
In the second study, investigators at the University of Manchester attempted to replicate nine variants identified in a previous report by the Wellcome Trust Case Control Consortium and found rs6920220, which also maps to 6q23.
Although these variants are not located in a gene, they are between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-induced protein 3 (TNFAIP3). The University of Manchester authors suggest that TNFAIP3 is a plausible candidate to explain the effects of these markers given its involvement in inflammatory processes.