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Jan 8, 2008

Seattle Genetics Earns $4M Milestone Fee from Genentech

  • Seattle Genetics will receive a $4 million milestone payment from Genentech as a result of Genentech initiating a Phase Ib trial of SGN-40. The study will investigate the compound in combination with Rituxan® in patients with relapsed follicular or marginal zone non-Hodgkin's lymphoma.

    The deal related to SGN-40 was inked in January 2007. Seattle Genetics received an upfront payment of $60 million and is entitled to get potential milestone fees exceeding $800 million and escalating double-digit royalties starting in the mid-teens.

    “Preclinical data suggests that the combination of SGN-40 and Rituxan may have enhanced activity compared to either agent alone in multiple models of non-Hodgkin's lymphoma, providing support for testing this combination in the clinical setting,” notes Thomas C. Reynolds, M.D., Ph.D., CMO of Seattle Genetics.

    “In collaboration with Genentech, we are conducting a joint development plan for SGN-40, a humanized monoclonal antibody, that includes six ongoing or planned clinical trials of SGN-40 both as a single agent and combined with standard therapies for non-Hodgkin's lymphoma and multiple myeloma.”

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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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