GEN Exclusives

More »

GEN News Highlights

More »
Jan 8, 2008

Seattle Genetics Earns $4M Milestone Fee from Genentech

  • Seattle Genetics will receive a $4 million milestone payment from Genentech as a result of Genentech initiating a Phase Ib trial of SGN-40. The study will investigate the compound in combination with Rituxan® in patients with relapsed follicular or marginal zone non-Hodgkin's lymphoma.

    The deal related to SGN-40 was inked in January 2007. Seattle Genetics received an upfront payment of $60 million and is entitled to get potential milestone fees exceeding $800 million and escalating double-digit royalties starting in the mid-teens.

    “Preclinical data suggests that the combination of SGN-40 and Rituxan may have enhanced activity compared to either agent alone in multiple models of non-Hodgkin's lymphoma, providing support for testing this combination in the clinical setting,” notes Thomas C. Reynolds, M.D., Ph.D., CMO of Seattle Genetics.

    “In collaboration with Genentech, we are conducting a joint development plan for SGN-40, a humanized monoclonal antibody, that includes six ongoing or planned clinical trials of SGN-40 both as a single agent and combined with standard therapies for non-Hodgkin's lymphoma and multiple myeloma.”


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »