GEN Exclusives

More »

GEN News Highlights

More »
Sep 11, 2007

Scientists Identify Sugar Essential for Malaria Invasion

  • Researchers at the Johns Hopkins Malaria Research Institute identified a sugar in mosquitoes that allows the malaria-causing parasite, Plasmodium falciparum, to attach itself to the mosquito’s gut.

    Invasion of the midgut cell layer is an essential stage in the parasite’s lifecycle and in the transmission of malaria from mosquitoes to humans. By reducing the level of the sugar, chondroitin sulfate, in the mosquito, the researchers prevented 95% of the parasites from attaching to the gut, thus blocking its development.

    To determine whether the parasite utilizes chondroitin glycosaminoglycans to invade the mosquito midgut cells, the researchers used RNAi to inhibit production of a mosquito enzyme that is needed to produce chondroitin sulfate. With the sugar removed, parasite adhesion and midgut invasion were substantially decreased.

    The study is published in the online early edition of Proceedings of the National Academy of Sciences.



Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Alzheimer's Therapies

Do you think an effective treatment for Alzheimer’s will be found within the next 10–15 years?