Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Nov 30, 2006

Scan of Human Genome Finds Unexpected New Clues on Lou Gehrig’s Disease

  • A comprehensive scan of the human genome has identified more than 50 genetic abnormalities in people with sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease), the Muscular Dystrophy Association and the Translational Genomics Research Institute (TGen) reported. TGen researchers say the identified differences implicate genes likely to play a role in cell function that controls nerve adhesion, offering a new avenue for ALS research.

    “Our findings indicate these genes produce a sort of molecular glue that attaches motor neurons to muscle,” explains Dietrich Stephan, TGen director of Neurogenomics. “It appears that in ALS the nerve is able to peel off the muscle and when that happens repeatedly, the nerves die.”

    TGen researchers identified the differences by screening DNA samples from over 1,200 people with and 2,000 people without sporadic ALS using microarray technology from Affymetrix.


GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

What Does Brexit Mean for Biotech?

Do you agree with the contention that Brexit will NOT have a long-term negative impact on the British biotech industry?

More »