Scientists at the Karolinska Institutet identified the genes that can combat atherosclerosis by reducing levels of bad cholesterol in the blood.
In their study on mice, the research group showed that plaque accumulation can be prevented if levels of LDL cholesterol are reduced before atherosclerotic plaque has progressed beyond a particular point. The group also report identifying a network of 37 genes that lowers levels of blood cholesterol and brings about this beneficial effect.
Researchers from the Karolinska Institutet were assisted by scientists at Linköping University. The study is published online on March 14 in PLoS Genetics.