GEN Exclusives

More »

GEN News Highlights

More »
Jan 29, 2008

Researchers Identify a Mechanism for Cervical Cancer Progression

  • Scientists report on how cell signaling in the stroma plays a role in the progression of cervical cancer. Using a mouse model of cervical cancer, the researchers looked at a protein that is made by the tumor cells known as platelet-derived growth factor (PDGF).

    They found that blocking PDGF signaling in cancer-associated fibroblasts and pericytes reduced the progression of new precancerous legions and halted the growth of already existing ones. The team also found that restoring signaling of PDGF causes a resumption of tumor growth

    Further investigation showed that blocking PDGF prevents the expression of angiogenic factor fibroblast growth factor 2 (FGF-2) and the epithelial cell growth factor FGF-7 by cancer-associated fibroblasts.

    The study was conducted by investigators at the University of California, San Francisco and Ludwig Institute for Cancer Research. The study was published on January 29 in PLoS Medicine.


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »