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Jan 29, 2008

Researchers Identify a Mechanism for Cervical Cancer Progression

  • Scientists report on how cell signaling in the stroma plays a role in the progression of cervical cancer. Using a mouse model of cervical cancer, the researchers looked at a protein that is made by the tumor cells known as platelet-derived growth factor (PDGF).

    They found that blocking PDGF signaling in cancer-associated fibroblasts and pericytes reduced the progression of new precancerous legions and halted the growth of already existing ones. The team also found that restoring signaling of PDGF causes a resumption of tumor growth

    Further investigation showed that blocking PDGF prevents the expression of angiogenic factor fibroblast growth factor 2 (FGF-2) and the epithelial cell growth factor FGF-7 by cancer-associated fibroblasts.

    The study was conducted by investigators at the University of California, San Francisco and Ludwig Institute for Cancer Research. The study was published on January 29 in PLoS Medicine.



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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