Researchers from the Max Planck Institute of Biochemistry uncovered over 5,000 proteins that are present in mouse embryonic stem cells. Around 1,700 proteins have already been identified in stem cells.
Using mass spectrometry and special heavy amino acids made with carbon-13, the Max-Plank team report that they quantified 5,111 distinct mouse stem-cell proteins. As expected, a good portion of these proteins are involved in rapid cell growth, but overall, the proteome encompassed a broad range of cell functions.
The study is published in the April issue of Molecular and Cellular Proteomics.