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Dec 20, 2011

ProteoTech, GSK Come Together for Parkinson Drug R&D

  • GlaxoSmithKline (GSK) has decided to help ProteoTech advance work in its alpha-synuclein therapeutic program. The companies aim to identify small molecules against misfolded proteins to treat Parkinson disease and other synucleinopathies.

    ProteoTech's lead small molecule, Synuclere™, targets alpha-synuclein aggregation and is currently in late preclinical stages of development. Initial support for this program was funded over a four-year period by the Michael J. Fox Foundation for Parkinson’s Research.

    ProteoTech is a private drug development company located in the Seattle, WA. Besides the Synuclere program, ProteoTech is developing Exebryl-1® for the treatment of diseases caused by beta-amyloid protein and tau protein aggregates and fibrils, like Alzheimer disease.

    Additionally, the firm is in early clinical studies with Systebryl™ for the treatment of systemic AA amyloidosis. ProteoTech is also in late preclinical development for a small peptide (Pepticlere™) for the treatment of Alzheimer disease beta-amyloid protein aggregates.

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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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