GEN Exclusives

More »

GEN News Highlights

More »
Apr 7, 2009

Protein that Controls Intestinal Colonization with Bacteria Revealed

  • Investigators from Erasmus Medical Center, The Netherlands, uncovered a role for the protein Cd1d in regulating intestinal colonization by bacteria in mice. They report that the protein exerts its control through mechanisms that include the control of Paneth cell function.

    Reporting in the Journal of Clinical Investigation in a paper called “Cd1d-dependent regulation of bacterial colonization in the intestine of mice,” the team analyzed Cd1d-sufficient and Cd1d-deficient mice. Under specific pathogen-free or germ-free conditions, they administered a number of species of bacteria like P. aeruginosa, E. coli, S. aureus, or L. gasseri.

    Compared with Cd1d-sufficient mice, Cd1d-deficient mice exhibited increased colonization of the small intestine after these bacteria were administered into their stomachs, according to the researchers. In contrast, activation of Cd1d-restricted T cells (NKT cells) diminished intestinal colonization with the same bacterial strains.

    The scientists also found differences in the composition of intestinal microbiota, including increased adherent bacteria in Cd1d-deficient mice under specific pathogen–free conditions. Germ-free Cd1d-deficient mice exhibited a defect in Paneth cell granule ultrastructure and ability to degranulate after bacterial colonization. In vitro, NKT cells were shown to induce the release of lysozyme from intestinal crypts.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »