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Mar 21, 2008

Protein Involved in Uncontrolled Tumor Growth Uncovered

  • New data indicates that the protein TM4SF5 has a crucial role in the ability of human hepatocarcinoma cells to overcome contact inhibition and grow in an uncontrolled manner.

    Researchers observed that TM4SF5 was overexpressed in human hepatocarcinoma tissue. This mediated cellular effects that caused the tumor cells to undergo a process known as epithelial-mesenchymal transition and resulted in uncontrolled growth both in vitro and when the cells were injected into mice.

    The scientists involved in the study were from Seoul National University, Gyeongsang National University, Kyungpook National University School of Medicine, Tokyo Medical and Dental University, and Korea Research Institute of Bioscience and Biotechnology. The study was published in the March 20 edition of the Journal of Clinical Investigation.

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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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