Pfizer will acquire an exclusive worldwide license to Quark Biotech’s human gene RTP-801
and to molecules that modify its expression or function under a new agreement between the two companies. RTP-801
is involved in the development of pathologic blood vessels that accelerate the progression of age-related macular degeneration (AMD).
Based on preclinical models, it is believed that AMD can be treated by blocking the expression of the RTP-801 gene through RNA interference or RNAi.
“We are excited about the potential of RTP-801 to preserve vision in patients with wet AMD who have an increased risk of progressive eye damage and vision loss,” says Martin Mackay, Ph.D., Pfizer senior vp worldwide research and technology.