GEN Exclusives

More »

GEN News Highlights

More »
Sep 6, 2012

Partnership Looks to Epigenetic Target for Blood Cancer Therapy

  • Astex Pharmaceuticals is teaming up with the U.K.’s Cancer Research Technology (CRT), and the Institute of Cancer Research (ICR) for a collaboration focused on the discovery and development of drug candidates against a specified epigenetic target for blood cancer. The partnership will marry Astex’s fragment-based drug discovery platform and epigenetic drug development capabilities with ICR’s expertise in blood cancer biology, and the drug discovery capabilities of the Cancer Research U.K. Cancer Therapeutics Unit at the ICR.

    “We are delighted to be entering into this new collaboration with the ICR and CRT on a key epigenetics target,” comments Harren Jhoti, Ph.D., Astex president. “This new partnership builds on the highly successful collaboration which Astex entered into with the ICR and CRT in 2003 on another cancer target, PKB/Akt. That collaboration led to the discovery of two clinical candidates, the first of which, AZD5363, was taken into Phase I by our partner AstraZeneca in early 2011, and the second of which, AT13148, is being prepared to be taken into Phase I under our development partnership with Cancer Research U.K.”

Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »